CLL ICD-10-CM Codes | 2025

What ICD-10 codes are used for CLL?

Fully called chronic lymphocytic leukemia, CLL is a prevalent form of leukemia, and healthcare providers must accurately code and document this condition using ICD-10 codes. These alphanumeric codes enable the systematic classification and billing of medical conditions. 

Here are commonly used CLL ICD-10 codes, each accompanied by clinical descriptions:

• C91.10 - Chronic lymphocytic leukemia of B-cell type not having achieved remission: This code designates patients with active CLL who have not attained remission, indicating the ongoing nature of the disease.
• C91.11 - Chronic lymphocytic leukemia of B-cell type in remission: This code documents the patient's improved condition when CLL is under control and in remission.
• C91.12 - Chronic lymphocytic leukemia of B-cell type in relapse: In cases where CLL reoccurs after remission, this code denotes disease relapse.
• R59.9 - Enlarged lymph nodes, unspecified: Swollen lymph nodes are a common manifestation of CLL; this code is applicable when the cause of lymph node enlargement is not precisely identified.
• R53.81 - Other malaise: CLL patients may experience a general feeling of discomfort or malaise, and this code represents such symptoms associated with the disease.
• Z85.6 - Personal history of leukemia: This code acknowledges the medical history of individuals with a history of CLL who are currently in remission or have successfully overcome the disease.

Accurate documentation and coding of CLL using ICD-10 codes are pivotal for medical and billing purposes. These codes help healthcare professionals and insurance providers understand the specific status of CLL, its complications, and the patient's history, ensuring appropriate care and reimbursement.

Which CLL ICD codes are billable?

All the aforementioned ICD codes are valid and billable.

It's important to note that specific billing practices may vary depending on healthcare providers and insurance companies, so it's always recommended to consult with coding specialists or medical billing professionals to ensure accurate and appropriate billing for CLL cases.

Clinical information

• CLL is a chronic leukemia characterized by an overproduction of abnormal white blood cells (lymphocytes).
• It primarily affects B-lymphocytes (white blood cells) in the bone marrow and blood.
• CLL often progresses slowly and may not cause symptoms in its early stages, making it challenging to diagnose.
• Common clinical features of CLL include swollen lymph nodes, fatigue, night sweats, unintentional weight loss, and susceptibility to infections.
• Accurate ICD-10 coding for CLL is essential for billing, documentation, and tracking the progression of the disease.
• ICD-10 codes reflect the status of the disease, such as remission, relapse, or transformation to a more aggressive form.
• Complications like thrombocytopenia (low platelet count) and other symptoms like malaise may also require specific ICD-10 coding.
• Some codes, such as those for general malaise or personal history of leukemia, are not typically billable for treatment but serve a diagnostic and historical purpose.
• The choice of ICD-10 codes depends on the patient's clinical presentation and the specific details of their CLL diagnosis, ensuring that healthcare providers can accurately describe the condition and receive appropriate reimbursement.

Synonyms include

• Leukemia of B-cell type
• B-cell chronic lymphoid leukemia
• Small lymphocytic lymphoma (SLL)
• CLL/SLL (when combined with another type called small lymphocytic lymphoma)
• B-cell prolymphocytic leukemia (in cases of transformation)
• B-CLL (abbreviated form)
• Cell lymphoma due to leukemia
• Leukemia with bone marrow involvement
• Chronic lymphocytic leukemia (CLL)
• Chronic lymphocytic leukaemia
• Malignant neoplasms due to chronic lymphocytic leukemia

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